Skip to product information
1 of 3

Endotelio 1-MNA

Edotelio 1-MNA is a groundbreaking molecule that has shown promising results in blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is implicated in various conditions such as metabolic health, brain health, and cellular health. By blocking NNMT, NAD levels can be optimized safely. 

1-MNA, which stands for 1-methylnicotinamide, is a natural byproduct of nicotinic acid and nicotinamide, both primary variants of vitamin B3. Along with optimizing NAD levels, research indicates that 1-MNA is anti-inflammatory and plays a role in supporting the health of the vascular endothelium and the cardiovascular system. Given its potential benefits, 1-MNA can be considered a daily supplement for most individuals.

  • Known to be safe and well-tolerated
  • Renowned for its anti-inflammatory and anti-atherosclerotic qualities
  • Lowers levels of inflammatory markers
  • Essential for maintaining vascular endothelial function and stimulating synthesis of prostacyclin (PGI2)
  • Bolsters the secretory function of the vascular endothelium, thereby safeguarding against dysfunction
  • Minimizes the risk of blood clot formation and inflammation via PGI2 synthesis.
  • Enhances the stability of sirtuins (Sirt1), which in certain biological models has been associated with extended lifespan
  • Considered a groundbreaking molecule with potent anti-inflammatory and anti-atherosclerotic effects
  • Leading research institutions suggest 1-MNA may extend human lifespan
  • Elevated levels of 1-MNA during exercise and fasting suggest that its consumption, particularly during endurance training, could enhance exercise capacity and improve performance

Ingredients: cellulose (bulking agent), hydroxypropyl methylcellulose (glazing agent), 1-methylnicotinamide chloride (1-MNA), silicon dioxide (anticaking agent), titanium dioxide (colouring agent).

  • Regulating NAD

    1-MNA plays a crucial role in regulating NAD metabolism in the body, blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is a key regulator of the delicate redox balance, thereby restoring cellular health and optimizing NAD levels.

  • Award-Winning

    Endotelio's 1-MNA is a high-quality dietary supplement, synthesized through a unique technology developed in collaboration with European universities, manufactured in a GMP-certified facility in Eastern Europe, and has been recognized with awards for its groundbreaking contribution to cellular health.

  • Wide Reaching Benefits

    1-MNA has been recognized for its anti-inflammatory and anti-thrombotic properties, along with its unique ability to improve cell energy metabolism.

Safety & Tolerability

1-MNA, has vitamin origins and is also found in natural sources. Research has consistently shown that 1-MNA is both safe and well-tolerated in humans. The European Food Safety Authority (EFSA) has conducted a thorough assessment of 1-MNA's safety, confirming its safe usage(1).

(1) EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D, et al. "Scientific Opinion: Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97." EFSA Journal 2017; 15(10): 5001. Electronic publication available here.

Proudly from Colorado

Optimizing Human Potential (OHP Health) originated in the picturesque city of Boulder, Colorado, nestled at the base of the majestic Flatiron mountains. We offer an extensive range of supplements from industry-leading partners, including Prodrome, Arterosil, and Xymogen, among others. Should you have any inquiries, simply utilize the chat feature located at the bottom right of your screen; we're here to assist you from 9 am to 5 pm.