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Endotelio 1-MNA

Edotelio 1-MNA is a groundbreaking molecule that has shown promising results in blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is implicated in various conditions such as metabolic health, brain health, and cellular health. By blocking NNMT, NAD levels can be optimized safely. 

1-MNA, which stands for 1-methylnicotinamide, is a natural byproduct of nicotinic acid and nicotinamide, both primary variants of vitamin B3. Along with optimizing NAD levels, research indicates that 1-MNA is anti-inflammatory and plays a role in supporting the health of the vascular endothelium and the cardiovascular system. Given its potential benefits, 1-MNA can be considered a daily supplement for most individuals.

  • Known to be safe and well-tolerated
  • Renowned for its anti-inflammatory and anti-atherosclerotic qualities
  • Lowers levels of inflammatory markers
  • Essential for maintaining vascular endothelial function and stimulating synthesis of prostacyclin (PGI2)
  • Bolsters the secretory function of the vascular endothelium, thereby safeguarding against dysfunction
  • Minimizes the risk of blood clot formation and inflammation via PGI2 synthesis.
  • Enhances the stability of sirtuins (Sirt1), which in certain biological models has been associated with extended lifespan
  • Considered a groundbreaking molecule with potent anti-inflammatory and anti-atherosclerotic effects
  • Leading research institutions suggest 1-MNA may extend human lifespan
  • Elevated levels of 1-MNA during exercise and fasting suggest that its consumption, particularly during endurance training, could enhance exercise capacity and improve performance

Ingredients: cellulose (bulking agent), hydroxypropyl methylcellulose (glazing agent), 1-methylnicotinamide chloride (1-MNA), silicon dioxide (anticaking agent), titanium dioxide (colouring agent).

$89.00
  • Regulating NAD

    1-MNA plays a crucial role in regulating NAD metabolism in the body, blocking the enzyme Nicotinamide N-methyltransferase (NNMT), which is a key regulator of the delicate redox balance, thereby restoring cellular health and optimizing NAD levels.

  • Award-Winning

    Endotelio's 1-MNA is a high-quality dietary supplement, synthesized through a unique technology developed in collaboration with European universities, manufactured in a GMP-certified facility in Eastern Europe, and has been recognized with awards for its groundbreaking contribution to cellular health.

  • Wide Reaching Benefits

    1-MNA has been recognized for its anti-inflammatory and anti-thrombotic properties, along with its unique ability to improve cell energy metabolism.

Safety & Tolerability

1-MNA, has vitamin origins and is also found in natural sources. Research has consistently shown that 1-MNA is both safe and well-tolerated in humans. The European Food Safety Authority (EFSA) has conducted a thorough assessment of 1-MNA's safety, confirming its safe usage(1).

(1) EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D, et al. "Scientific Opinion: Safety of 1-methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97." EFSA Journal 2017; 15(10): 5001. Electronic publication available here.

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