Melatonin is a hormone secreted by the Pineal Gland and it is one of the master signals controlling circadian rhythms. Its secretion is affected by factors such as age, light, environmental and physiological factors. Melatonin is a key regulator of our internal biological clocks and energy metabolism, and it functions as an antioxidant and as an anti‐inflammatory agent. There is more and more evidence supporting the beneficial effects of melatonin supplementation on obesity and its complications partly due to its regulation of our satiety hormones, leptin and adiponectin.These results support the concept of melatonin as a potential therapeutic agent for obesity and many other disorders. Moreover, lower levels of melatonin secretion speed aging, tumor formation, fat accumulation (especially dangerous belly fat) and heart function.Recommended dose is typically between 3 and 5mg for helping reset circadian rhythms. Interestingly, we often use very high doses to help inflammation and pain!
1) Regulation of myocardial metabolism by the cardiomyocyte circadian clock.
Chatham JC, Young MEJ Mol Cell Cardiol. 2013 Feb; 55():139-46.
2) Farhud D, Aryan Z. Circadian Rhythm, Lifestyle and Health: A Narrative Review. Iran J Public Health. 2018;47(8):1068-1076.3) Mundey K et al, Phase-dependent treatment of delayed sleep phase syndrome with melatonin (2005)Kayumov L, et al, A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome (2001)4) Revell VL, Burgess HJ, Gazda CJ, et al, Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light (J Clin Endocrinol Metab. 2006Jan;91(1)) 5) McArthur AJ et al, Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment (1996)
6) Lemoine P, et al, Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal (2011)
7) Brown GM, Light, Melatonin and the Sleep-Wake Cycle (1994)
Srinivasan V, Spence DW et al, Jet lag: therapeutic use of melatonin and possible application of melatonin analogs (2008)
8) Breslow ER, Phillips AJK, Huang JM, et al, A Mathematical Model of the Circadian Phase-Shifting Effects of Exogenous Melatonin (2013)
9) Nagtegaal JE, Kerkhof GA, Smits MG et al, Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset (J Sleep Res. 1998 Jun;7(2):135-43
10) Alexander, Scott, Melatonin: Much More Than You Wanted To Know (Slate Star Codex, July 10, 2018)