Leptin Gen | 30 capsules

Leptin Gen is formulated to influence genes that normalize leptin production and response to assist with fat loss and reduce inflammation.
(No reviews yet) Write a Review

Much of obesity has a genetic influence. Genes encoding for the body’s production of and response to the protein leptin play a major role in the regulation of body weight. Leptin functions as part of a signaling pathway that can inhibit food intake and regulate energy expenditure to reduce adipose tissue. This protein is also involved in the regulation of immune and inflammatory responses.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 30 Capsules


Does Not Contain:
Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
Journal References:
1. Jéquier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci. 2002 Jun;967:379-88. [PMID: 12079865] 
2. Fukuda M, Williams KW, Gautron L, et al. Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab. 2011 Mar 2;13(3):331-39. [PMID: 21356522] 
3. Lin L, Martin R, Schaffhauser AO, et al. Acute changes in the response to peripheral leptin with alteration in the diet composition. Am J Physiol Regul Integr Comp Physiol. 2001 Feb;280(2):R504-09. [PMID: 11208581] 
4. Wang J, Obici S, Morgan K, et al. Overfeeding rapidly induces leptin and insulin resistance. Diabetes. 2001 Dec;50(12):2786-91. [PMID: 11723062] 
5. Shapiro A, Mu W, Roncal C, et al. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1370-75. [PMID: 18703413]
 6. Vasselli JR, Scarpace PJ, Harris RB, et al. Dietary components in the development of leptin resistance. Adv Nutr. 2013 Mar 1;4(2):164-75. [PMID: 23493533] 
7. Leon-Cabrera S, Solís-Lozano L, Suárez-Álvarez K, et al. Hyperleptinemia is associated with parameters of low-grade systemic inflammation and metabolic dysfunction in obese human beings. Front Integr Neurosci. 2013 Aug 23;7:62. [PMID: 23986664] 
8. Cross-talk between the adipogenic and the chondrogenic programs elicited by a glycosaminoglycan mixture. Barcelona, Spain: Bioiberica S.A.; 2013. [on file] 
9. A glycosaminoglycan-rich commercial preparation used in osteoarthritis management favors fat loss in diet-induced obese mice. Barcelona, Spain: Bioiberica S.A.; 2013. [on file] 
10. Wu W, Zvirbulis R, Zonca B, et al. An oral preparation containing hyaluronic acid (Oralvisc®) can significantly decrease the production of leptin levels in the serum and synovial fluid of osteoarthritic knee patients. Poster presented at: Orthopaedic Research Society (ORS) Annual Meeting. San Antonio, TX. January 26-29, 2013. [on file]
 11. Wu W, Pasierb M, Zonca, B et al. An oral preparation containing hyaluronic acid (Oralvisc®) can act systemically to decrease serum and synovial fluid levels of inflammatory cytokines and chemokines in osteoarthritic knee patients. Oral communication at: Orthopaedic Research Society (ORS) Annual Meeting. San Antonio, TX January 26-29, 2013. [on file]
12.Nature 392, 398-401 (26 March 1998) | doi:10.1038/32911; Received 30 October 1997; Accepted 20 February 1998
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction Karine Clément, Christian Vaisse, Najiba Lahlou, Sylvie Cabrol, Veronique Pelloux, Dominique Cassuto, Micheline Gourmelen, Christian Dina, Jean Chambaz, Jean-Marc Lacorte, Arnaud Basdevant, Pierre Bougnères, Yves Lebouc, Philippe Froguel & Bernard Guy-Grand